Our Research Interests
Our lab seeks to understand how the human brain develops and how disruptions in this process contribute to neurodevelopmental conditions associated with intellectual disability, including Autism Spectrum Disorder and Down syndrome. Our overarching goal is to build a detailed molecular and cellular map of the developing human brain to identify the gene networks and cell-type–specific mechanisms that shape neurodevelopment and cognition.
To address these questions, we combine mouse models and human pluripotent stem cells (hPSCs) with genomic, molecular, and functional approaches. By studying how genetic variation alters brain development at the cellular and circuit levels, we aim to uncover fundamental principles of neurodevelopment and identify points where intervention may be possible.
Our work is collaborative and translational. By partnering with scientists, clinicians, and families, we aim to translate cellular and molecular insights into therapeutic strategies that may ultimately improve outcomes and quality of life for individuals with neurodevelopmental disorders.