Watson, L. A. & Meharena, H. S. From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome. Front Genet 14, 1198129, doi:10.3389/fgene.2023.1198129 (2023).
Meharena, H.S.*, Marco, A., Dileep, V., Lockshin, E.R., Akatsu, G.Y., Mulalahoo, J., Watson, L.A., Ko, T.., Guerin, L.N., Abdurob, F., Rengarajan, S., Papanastasiou, M., Jaffe, J.D., & Tsai, L.-H.* (2022). Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors. Cell Stem Cell 29, 116-130 e117.
* - Co-corresponding authors
Marco, A., Meharena, H.S., Dileep, V., Raju, R.M., Davila-Velderrain, J., Zhang, A.L., Adaikkan, C., Young, J.Z., Gao, F., Kellis, M., & Tsai, L.-H. (2020). Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble. Nat. Neurosci. 23, 1606-1617.
Dileep, V., Boix, C.A., Mathys, H., Marco, A., Welch, G.M., Meharena, H.S., Loon, A., Jeloka, R., Peng, Z., Bennett, D.A., et al. (2023). Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration. Cell 186, 4404-4421 e4420.
Watson, L.A. & Tsai, L.-H. (2016). In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory. Curr. Opin. Neurobiol. 43, 48-55.
Victor, M. B., Leary, N., Luna, X., Meharena, H. S., Scannail, A. N., Bozzelli, P. L., Samaan, G., Murdock, M. H., von Maydell, D., Effenberger, A. H., Cerit, O., Wen, H. L., Liu, L., Welch, G., Bonner, M. & Tsai, L. H. Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity. Cell Stem Cell 29, 1197-1212 e1198, doi:10.1016/j.stem.2022.07.005 (2022).
Morshed, N., Ralvenius, W.T., Nott, A., Watson, L.A., Rosriguez, F.H., Akay, L.A., Joughin, B.A., Pao, P.C., Penney, J., LaRocque, L., Mastroeni, S., Tsai, L.-H., & White, F.M. (2020). Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration. Mol. Syst. Biol. 16, e9819.
Pao, P.C., Patnaik, D., Watson, L.A., Gao, F., Pan, L., Wang, J., Adaikkan, C., Penney, J., Cam, H.P., Huang, W.C., Pantano, L., Lee, A., Nott, A., Phan, T.X., Gjoneska, E., Elmsaouri, S., Haggarty, S.J., & Tsai, L.-H. (2020). HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease. Nat. Commun. 11, 2484.
Canter, R.G., Huang, W.C., Choi, H., Wang, J., Watson, L.A., Yao, C.G., Abdurrob, F., Bousleiman, S.M., Young, J.Z., Bennett, D.A., Delalle, I., Chung, K., & Tsai, L.-H. (2019). 3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice. Commun. Biol. 2, 360.
Taylor, S.S., Meharena, H.S., & Kornev, A.P. (2019). Evolution of a dynamic molecular switch. IUBMB Life 71, 672-684.
Elbert, A., Vogt, D., Watson, L.A., Levy, M., Jiang, Y., Brûlé, E., Rowland, M.E., Rubenstein, J., & Bérubé, N.G. (2019). CTCF governs the identity and migration of MGE-derived cortical interneurons. J. Neurosci. 39, 177-192.
Seo, J., Kritskiy, O., Watson, L.A., Barker, S.J., Dey, D., Raja, W., Lin, Y.-T., Ko, T., Cho, S., Penney, J., Silva, M.C., Sheridan, S., Lucente, D., Gusella, J., Dickerson, B., Haggarty, S.J., & Tsai, L.-H. (2017). Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia. J. Neurosci. 37, 9917-9924.
Watson, L.A. & Tsai, L.-H. (2017). Molecular biology: Local metabolites linked to memory. Nature 546, 361-362.
Durak, O., Gao, F., Kaeser-Woo, Y.J., Rueda, R., Martorel, A.J., Nott, A., Liu, C.Y., Watson, L.A., & Tsai, L.-H. (2016). Chd8 mediates cortical neurogenesis through transcriptional regulation of cell cycle and Wnt signalling genes. Nat. Neurosci. 19, 1477-1488.
Meharena, H.S.*, Fan, X., Ahuja, L.G., Keshwani, M.M., McClendon, C.L., N., Adams, J.A., & Taylor, S.S.* (2016). Decoding the interactions regulating the active state mechanics of eukaryotic protein kinases. PLoS Biol. 2016 Nov 30;14(11):e200012 (* - Co-corresponding authors)
Watson, L.A., Goldberg, H., & Bérubé, N.G. (2015). Emerging roles of ATRX in cancer. Epigenomics. 7, 1365-78.
Hu, J., Ahuja, L.G., Meharena, H.S., Kannan, N., Kornev, A.P., Taylor, S.S., & Shaw, A.S. (2015). Kinase regulation by hydrophobic spine assembly in cancer. Mol. Cell Biol. 35, 264-276.
Pence, M.A., Haste, N.M., Meharena, H.S., Olson, J., Gallo, R.L., Nizet, V., and Kristian, S.A. (2015). Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. PloS one 10, e0136605.
Zan, J., Choi, O., Meharena, H.S., Uhlson, C.L., Churchill, M.E., Hill, R.T., and Fuqua, C. (2015). A solo luxI-type gene directs acylhomoserine lactone synthesis and contributes to motility control in the marine sponge symbiont Ruegeria sp. KLH11. Microbiology 161, 50-56.
Ritchie, K., Watson, L.A., Davidson, B., Jiang, Y., & Bérubé, N.G. (2014). ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain. Biol. Open, 3, 1158-1163.
Watson, L.A., Wang, X., Elbert, A., Kernohan, K., Galjart, N., & Bérubé, N.G. (2014). Dual effect of CTCF loss on neuroprogenitor differentiation and survival. J. Neurosci. 34, 2860-2870.
Solomon, L.A., Russell, B.A., Watson, L.A., Beier, F., & Bérubé, N.G. (2013). Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly. Hum. Mol. Genet. 22, 5015-5025.
Meharena, H.S., Chang, P., Keshwani, M.M., Oruganty, K., Nene, A.K., Kannan, N., Taylor, S.S., & Kornev, A.P. (2013). Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol 11, e100168.
Hu, J., Stites, E.C., Yu, H., Germino, E.A., Meharena, H.S., Stork, P.J., Kornev, A.P., Taylor, S.S., & Shaw, A.S. (2013). Allosteric activation of functionally asymmetric RAF kinase dimers. Cell 154, 1036-1046.
Watson, L.A., Solomon, L.A., Li, J.R., Jiang, Y., Edwards, M., Shin-ya, K., Beier, F., & Bérubé, N.G. (2013). Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J. Clin. Invest. 123, 2049–2063.
Zan, J., Cicirelli, E.M., Mohamed, N.M., Sibhatu, H.M., Kroll, S., Choi, O., Uhlson, C.L., Wysoczynski, C.L., Murphy, R.C., Churchill, M.E., Hill, R.T., and Fuqua, C. (2012). A complex LuxR-LuxI type quorum sensing network in a roseobacterial marine sponge symbiont activates flagellar motility and inhibits biofilm formation. Molecular microbiology 85, 916-933.
Churchill, M.E., Sibhatu, H.M., and Uhlson, C.L. (2011). Defining the structure and function of acyl-homoserine lactone autoinducers. Methods Mol Biol 692, 159-171.
Tizzano, M., Gulbransen, B.D., Vandenbeuch, A., Clapp, T.R., Herman, J.P., Sibhatu, H.M., Churchill, M.E., Silver, W.L., Kinnamon, S.C., and Finger, T.E. (2010). Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. Proc Natl Acad Sci USA 107, 3210-3215.
Li, H., Das, A., Sibhatu, H.M., Jamal, J., Sligar, S.G., and Poulos, T.L. (2008). Exploring the electron transfer properties of neuronal nitric-oxide synthase by reversal of the FMN redox potential. J Biol Chem 283, 34762-34772.