L. Ashley Watson, Zoe Adelsheim, Mackenzie J. Carter, Grace T. Carter, Karen L. Jimenez-Reyes, Huijie Du, Ziqing Zhu, David B. Berry, Mia C. Paredez, Rania H. Palaniappan, John M. Augustine, Hiruy S. Meharena. Persistent and transient senescent cells contribute to brain-barrier development. Cell: 10.1016/j.cell.2026.05.022
Meharena, H.S., Marco, A., Dileep, V., Lockshin, E.R., Akatsu, G.Y., Mulalahoo, J., Watson, L.A., Ko, T.., Guerin, L.N., Abdurob, F., Rengarajan, S., Papanastasiou, M., Jaffe, J.D., & Tsai, L.-H. Down syndrome induced senescence disrupts the nuclear architecture of neural progenitors. Cell Stem Cell. (2021) https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00486-0
Marco, A., Meharena, H.S., Dileep, V., Raju, R.M., Davila-Velderrain, J., Zhang, A.L., Adaikkan, C., Young, J.Z., Gao, F., Kellis, M., & Tsai, L.-H. (2020). Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble. Nat. Neurosci. 23, 1606-1617. https://www.nature.com/articles/s41593-020-00717-0
Morshed, N., Ralvenius, W.T., Nott, A., Watson, L.A., Rosriguez, F.H., Akay, L.A., Joughin, B.A., Pao, P.C., Penney, J., LaRocque, L., Mastroeni, S., Tsai, L.-H., & White, F.M. (2020). Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration. Mol. Syst. Biol. 16, e9819.
Pao, P.C., Patnaik, D., Watson, L.A., Gao, F., Pan, L., Wang, J., Adaikkan, C., Penney, J., Cam, H.P., Huang, W.C., Pantano, L., Lee, A., Nott, A., Phan, T.X., Gjoneska, E., Elmsaouri, S., Haggarty, S.J., & Tsai, L.-H. (2020). HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease. Nat. Commun. 11, 2484.
Canter, R.G., Huang, W.C., Choi, H., Wang, J., Watson, L.A., Yao, C.G., Abdurrob, F., Bousleiman, S.M., Young, J.Z., Bennett, D.A., Delalle, I., Chung, K., & Tsai, L.-H. (2019). 3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice. Commun. Biol. 2, 360.
Taylor, S.S., Meharena, H.S., & Kornev, A.P. (2019). Evolution of a dynamic molecular switch. IUBMB Life 71, 672-684.
Elbert, A., Vogt, D., Watson, L.A., Levy, M., Jiang, Y., Brûlé, E., Rowland, M.E., Rubenstein, J., & Bérubé, N.G. (2019). CTCF governs the identity and migration of MGE-derived cortical interneurons. J. Neurosci. 39, 177-192.
Seo, J., Kritskiy, O., Watson, L.A., Barker, S.J., Dey, D., Raja, W., Lin, Y.-T., Ko, T., Cho, S., Penney, J., Silva, M.C., Sheridan, S., Lucente, D., Gusella, J., Dickerson, B., Haggarty, S.J., & Tsai, L.-H. (2017). Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia. J. Neurosci. 37, 9917-9924.
Watson, L.A. & Tsai, L.-H. (2017). Molecular biology: Local metabolites linked to memory. Nature 546, 361-362.
Watson, L.A. & Tsai, L.-H. (2016). In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory. Curr. Opin. Neurobiol. 43, 48-55.
Durak, O., Gao, F., Kaeser-Woo, Y.J., Rueda, R., Martorel, A.J., Nott, A., Liu, C.Y., Watson, L.A., & Tsai, L.-H. (2016). Chd8 mediates cortical neurogenesis through transcriptional regulation of cell cycle and Wnt signalling genes. Nat. Neurosci. 19, 1477-1488.
Meharena, H.S., Fan, X., Ahuja, L.G., Keshwani, M.M., McClendon, C.L., N., Adams, J.A., & Taylor, S.S. (2016). Decoding the interactions regulating the active state mechanics of eukaryotic protein kinases. PLoS Biol. 2016 Nov 30;14(11):e200012
Watson, L.A., Goldberg, H., & Bérubé, N.G. (2015). Emerging roles of ATRX in cancer. Epigenomics. 7, 1365-78.
Hu, J., Ahuja, L.G., Meharena, H.S., Kannan, N., Kornev, A.P., Taylor, S.S., & Shaw, A.S. (2015). Kinase regulation by hydrophobic spine assembly in cancer. Mol. Cell Biol. 35, 264-276.
Ritchie, K., Watson, L.A., Davidson, B., Jiang, Y., & Bérubé, N.G. (2014). ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain. Biol. Open, 3, 1158-1163.
Watson, L.A., Wang, X., Elbert, A., Kernohan, K., Galjart, N., & Bérubé, N.G. (2014). Dual effect of CTCF loss on neuroprogenitor differentiation and survival. J. Neurosci. 34, 2860-2870.
Solomon, L.A., Russell, B.A., Watson, L.A., Beier, F., & Bérubé, N.G. (2013). Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly. Hum. Mol. Genet. 22, 5015-5025.
Meharena, H.S., Chang, P., Keshwani, M.M., Oruganty, K., Nene, A.K., Kannan, N., Taylor, S.S., & Kornev, A.P. (2013). Deciphering the structural basis of eukaryotic protein kinase regulation. PLoS Biol 11, e100168.
Hu, J., Stites, E.C., Yu, H., Germino, E.A., Meharena, H.S., Stork, P.J., Kornev, A.P., Taylor, S.S., & Shaw, A.S. (2013). Allosteric activation of functionally asymmetric RAF kinase dimers. Cell 154, 1036-1046.